Rongxin Fang (Principal investigator)

Rongxin is an Assistant Professor at Stanford University in the Departments of Neurosurgery and Genetics (by courtesy) and a member of the Wu Tsai Neuroscience Institute.

Rongxin received his Ph.D. in Bioinformatics and Systems Biology at UC San Diego, where he was advised by Bing Ren (2015-2019). During this time, he developed high-throughput genomic technologies and computational tools to map the structure and activity of the mammalian genome at a large scale with single-cell resolution. He then applied these approaches to understand how cis-regulatory elements such as enhancers in the genome control gene expression and how this process can give rise to the distinct gene expression programs that underlie the cellular diversity in the mammalian brain.

He was an HHMI-Damon Runyon Postdoctoral Fellow at Harvard University during 2019-2024. There, he developed and applied genome-scale and volumetric 3D transcriptome imaging methods to map the molecular and cellular architecture of the mammalian brain during evolution and aging. He also participated in the collaboration with Adam Cohen and Catherine Dulac to combine transcriptome imaging with functional neuronal recording to identify neuronal populations in the animal brain that underlie specific bran functions.

He has received multiple fellowships and awards, including the HHMI / Damon Runyon Postdoctoral Fellowship, Rising Star in Engineering in Health (Johns Hopkins & Columbia University), Next Generation Leaders (Allen Institute) and Damon Runyon-Dale F. Frey Award for Breakthrough Scientists.

His work has been supported by HHMI, Damon Runyon Cancer Research Foundation, 4D Nucleome, ENCODE Project, Roadmap Epigenome Consortia, and BRAIN Initiative.

Outside the lab, Rongxin enjoys long-distance running and biking.

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Current Members

  • Christine Ng

    Postdoctoral Fellow

    Christine received her Ph.D. in Chemistry from Stanford University under the supervision of Prof. Steven M. Banik. Her doctoral research focused on developing and applying chemical strategies to control the subcellular localization of proteins. She established Targeted Relocalization Activating Molecules (TRAMs), an induced-proximity platform that harnesses native protein trafficking to reprogram protein localization, and demonstrated its utility in redirecting disease-associated proteins and modulating axonal degeneration.

  • Zhiyuan Sun

    Postdoctoral Fellow

    Zhiyuan received his Ph.D. from the Southern University of Science and Technology under the supervision of Dr. Wei Chen. His doctoral work focused on post-transcriptional and translational gene regulation. He developed RNA editing-based approaches integrated with high-throughput sequencing for transcriptome-wide profiling of P-body-associated RNAs and mRNA translation efficiency.

  • Ziheng (Calvin) Chen

    Postdoctoral Fellow

    Calvin received his Ph.D. in Biological Sciences from Carnegie Mellon University, where he worked with Dr. Andreas Pfenning at the intersection of epigenomics, high-throughput screening, machine learning, and neuroscience. His doctoral work revealed context-dependent regulatory variants in Alzheimer’s disease. Previously, Calvin earned his M.S. in Biomedical Engineering from Columbia University, where he worked with Dr. Xuebing Wu. He also received his B.Sc. in Biochemistry from the University of Liverpool in the UK. Calvin is interested in uncovering the molecular causes of neurodegeneration and designing therapeutic strategies through high-throughput, experiment-informed generative AI approaches.

  • Ya Jiang

    Postdoctoral Fellow

    Ya earned her Ph.D. in genetics and molecular biology from Cornell University. She is broadly interested in how transcriptional and post-transcriptional mechanisms shape cellular function. Her previous work in Andrew Grimson’s lab identified transcriptional and epigenetic signatures that distinguish human adult and neonatal CD8⁺ T cells. There, she also contributed to the identification of microRNA target genes using PRO-seq and RNA-seq. Her goal is to better understand how these gene regulatory processes support neural plasticity and cognition.

  • Yue Sun

    Postdoctoral Fellow

    Yue is a collaborative postdoc from Kang Shen’s Lab at Stanford. She is broadly interested in ageing and neurodegeneration. Yue earned her Ph.D. in Biology from UC San Diego, where she trained in C. elegans genetics and neurobiology in Yishi Jin’s lab. There, she uncovered novel mechanisms regulating the stress-responsive DLK signaling pathway at the sensory endings of the nervous system. Outside the lab, she enjoys photography, visiting art museums, and playing badminton.

  • Owen Martin

    Postbac

    Owen earned his A.B. in Philosophy and Physics from Harvard in 2022. As an undergraduate, he developed computational pipelines to simulate galactic dynamics with Dr. João Alves at the Radcliffe Institute for Advanced Study. After graduation, he entered biomedicine by joining Dr. Nadia Alatrakchi’s lab at Harvard Medical School and Massachusetts General Hospital. Outside of work, he reflects on the proverbial good life and prioritizes extra-professional study, piano practice, and wellness through meditation, exercise, and vegan home cooking.

  • Chumo Chen

    Master Student in Biomedical Data Science

    Chumo earned his bachelor's degree in Molecular and Cell Biology from UC San Diego. Previously, he worked at Dr. Bing Ren's lab, where he used single-cell multiomics to study neurodegenerative diseases and aging. After graduation, he joined Dr. Joseph Ecker's lab at Salk Institute, where he generated multiomic datasets for BICAN.

  • Eduardo A. Chaparro Barriera

    Ph.D. Candidate in Biophysics

    Eduardo received his bachelor degree in Chemistry from the University of Puerto Rico–Mayagüez. His passion for neurobiology began as an AMGEN Scholar at UC Berkeley where, as part of Dr. Kumar’s lab, he studied the biophysics of neurofilament aggregation in disease states. Later, as a REACH Scholar at Stanford and in Dr. Zuchero’s lab, he studied myelin formation and compaction by combining exocytosis and calcium imaging. Outside the lab, Eduardo enjoys playing basketball and softball, and exploring new restaurants around the Bay Area.

  • Margarita Artiukhova

    Ph.D. Candidate in Molecular Cellular Physiology

    Margarita is a collaborative PhD student from Tom Sudhof's lab. Born in Eastern Europe, her path into science has taken many unexpected turns, both geographically and intellectually.  She earned her MSc in Neurobiology from the California Institute of Technology (Caltech). She is interested in uncovering mechanisms by which experience-driven neuronal activity promotes refinement of neural circuits.

  • Edith F. Zhou

    Lab mascot

    Hello! My name is Edith, and I was born in Sonoma, California, in June 2025. I am the mascot of the Fang Lab. My primary role is to provide emotional support, and bring smiles to lab members. I like apples, socks and making friends with humans of all ages.

Alumni

  • Aaron Alberto

    Role: Lab Manager
    Period: 2025-2025
    Last Seen: N/A

  • Rachel Youngwood

    Role: Summer Intern
    Period: 2025-2025
    Last Seen: Undergraduate at Stanford University

  • Salma Siddiqui

    Role: Summer Intern
    Period: 2025-2025
    Last Seen: Undergraduate at Harvard University

  • Asia Chen

    Role: Undergraduate
    Period: 2025-2025
    Last Seen: Undergraduate at Stanford University

  • Emma Bi

    Role: Postbac
    Period: 2025-2026
    Last Seen: PhD student at MIT