Advance Brain Health with Genomics & AI
THE LABORATORY OF NEUROGENOMICS
By integrating transcriptomics, optical imaging, synthetic biology, and machine learning, we build next-generation tools to decode the genetic basis of human brain health and disease.
THE CHALLENGE
Understanding how a brain cell encodes function in space remains one of the greatest challenges in biology. Within a single neuron, thousands of genes are expressed, yet cellular function depends not only on which RNAs a cell makes, but where they are localized - a spatial layer of gene regulation that remains poorly understood. Our research seeks to uncover how the spatial transcriptome is organized across brain cell types, how it is dynamically remodeled to support health and plasticity, how its disruption drives disease, and whether RNA localization can be sythetically designed to restore function, enhance brain plasticity, and promote longevity.
THE APPROACH
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IMAGE
We develop next-generation imaging-based spatial omics technologies to map the spatial transcriptome in the healthy and diseased brain with unprecedented molecular resolution and precision.
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MODEL
We leverage machine learning and artificial intelligence to uncover how RNA sequence encodes subcellular localization and how genetic variation disrupts its spatial organization.
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UNDERSTAND
We use high-throughput biochemical approaches to identify the molecular mechanisms and signaling pathways that govern RNA localization and drive its mislocalization in disease.
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CURE
Ultmately, we aim to translate these discoveries into therapies by developing synthetic and pharmacological strategies to reprogram aberrant RNA localization, restore cellular function, and improve brain health.
THE NEWS
2025-12-18: Ya Jiang is awarded the Dean’s Fellowship at Stanford University. Congratulations to Ya!
2025-12-10: The Fang Lab hosts its first Christmas holiday party.
2025-12-01: We welcome our new rotation student, Margarita from Molecular Cellular Physiology (MCP) PhD program, to the lab.
2025-09-30: We welcome our new master student, Chumo Chen from Biomedical Science Program, to the lab. He will conduct his master thesis with us. Welcome!