Advance Brain Health with Genomics & AI
THE LABORATORY OF NEUROGENOMICS
From epigenomics and spatial transcriptomics to machine learning and genome editing, we advance genomic tools to understand the epigenetic basis of human brain health and disease.
THE CHALLENGE
Understanding the human brain remains the humanity’s final frontier. Its extraordinary complexity — more than billions of cells, thousands of distinct cell types and trillions of connections — has historically limited our ability to uncover its fundamental operating principles. Our research seeks to understand how these distinct cell types arise epigenetically, how they connect functionally to sustain homeostasis in health, how these interactions become disrupted in disease, and whether targeted reprogramming of cellular networks can restore function, enhance plasticity and extend longevity.
THE APPROACH
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MAP
We develop next-generation epigenomic and spatial omics technologies to map the healthy and diseased human brain at molecular resolution with unprecedented population scale.
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MODEL
We apply ML / AI to large-scale spatial omics data to model the diseased brain tissue microenvironment and accelerate the development of personalized therapeutic strategies.
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UNDERSTAND
We use high-throughput epigenomic and biochemical approaches to identify mechanisms by which specific genes and signaling pathways causally drive aberrant cellular phenotypes in the diseased brain.
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CURE
Ultimately, we hope to transform discovery into therapy via targeted reprogramming of pathological cellular interactions using epigenetic and pharmacological approaches to restore healthy brain function.
THE TEAM
THE NEWS
2025-12-18: Ya Jiang is awarded the Dean’s Fellowship at Stanford University. Congratulations to Ya!
2025-12-10: The Fang Lab hosts its first Christmas holiday party.
2025-12-01: We welcome our new rotation student, Margarita from Molecular Cellular Physiology (MCP) PhD program, to the lab.
2025-09-30: We welcome our new master student, Chumo Chen from Biomedical Science Program, to the lab. He will conduct his master thesis with us. Welcome!