Advance Brain Health with Genomics & AI
THE LABORATORY OF NEUROGENOMICS
From single-cell and spatial omics to machine learning and functional genomics, we advance genomic tools to understand the genetic basis of human brain health and disease.
THE CHALLENGE
Understanding the human brain remains one of humanity’s final frontiers. Its extraordinary complexity—more than billions of cells and thousands of molecularly and anatomically distinct cell types—has historically limited our ability to chart its fundamental operating principles. A central challenge is to understand how these distinct, spatially organized cell types are functionally connected to sustain homeostatic cellular states in the healthy brain, how these interactions become disrupted in disease, and whether targeted reprogramming of these cellular networks can restore function and extend brain health and longevity.
THE APPROACH
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MAP
We develop next-generation spatial omics to map the healthy and diseased human brain at molecular resolution and unprecedented population scale.
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MODEL
We apply AI and machine learning to large-scale spatial omics data to model the tissue microenvironment of the diseased human brain and accelerate the development of personalized therapeutics.
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UNDERSTAND
We use high-throughput genomics and biochemical approaches to identify the molecular mechanisms by which specific genes and signaling pathways causally drive aberrant cellular phenotypes in the diseased brain.
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CURE
Ultimately, we aim to transform discovery into therapy via targeted reprogramming of pathological cellular interactions using genetic and pharmacological approaches to restore healthy cellular function.